Urolithin M5

SKU: orb2567322

Description

Urolithin M5 (Decarboxyellagic acid) is a neuraminidase inhibitor isolated from olive leaves with antiviral and anticancer and antitumor activities. Urolithin M5 can be used to study influenza A virus infection and SARS-CoV-2 infection.

Research Area

,Others

Key Properties

• CAS Number: 91485-02-8
• MW: 276.2
• Purity: 95.32%
• Formula: C₁₃H₈O₇
• SMILES: O=C1OC=2C(O)=C(O)C=CC2C3=C(O)C(O)=C(O)C=C13

Bioactivity

• Target IC50:
  Virus:3.74~16.51 μM|MDCK cells:CC50=227.4 μM
• In Vivo:
  Specific-pathogen-free female BALB/c mice weighing 16 to 18 g. A total of 200 mg/kg/d urolithin M5 treatment improved the survival rate to 50%, which was significantly higher than the vehicle group. These results indicated that 200 mg/kg/d urolithin M5 had a protective effect on PR8-infected mice.
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• In Vitro:
  The cytotoxicity of urolithin M5 was initially assessed using the MTT assay on MDCK cells. Urolithin M5 had a CC50 value of 227.4 μM. 25 μM urolithin M5 inhibited all virus growth, urolithin M5 was the most effective compound, with an IC50 ranging from 3.74 to 16.51 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

18504424