USP9X (C) Antibody, Rabbit Polyclonal

SKU: orb131886

Description

Rabbit polyclonal to USP9X. Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) is a member of the peptidase C19 family similar to ubiquitin-specific proteases. Though the USP9X gene is located on the X chromosome, it escapes X-inactivation. USP9X is a deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins; therefore, USP9X may play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. USP9X is an essential component of the TGF-beta/BMP signaling cascade. USP9X also regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. USP9X specifically hydrolyzes both Lys-29-and Lys-33-linked polyubiquitins chains, and specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Mutations in USP9X have been associated with Turner syndrome.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: IP, WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human, Mouse
• Application Notes:
  < strong>WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; < br>< strong>Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of mouse USP9X, and provided as whole antiserum.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of mouse USP9X
• Molecular Weight: 291
• Purity: Whole Antiserum
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti Probable ubiquitin carboxyl-terminal hydrolase FAF-X antibody, anti Deubiquitinating enzyme FAF-X antibody, anti Fat facets homolog antibody, anti Fat facets protein-related antibody, anti X-linked antibody, anti Ubiquitin carboxyl-terminal hydrolase FAM antibody, anti Ubiquitin thioesterase FAF-X antibody, anti Ubiquitin-specific protease 9 antibody, anti X chromosome antibody, anti Ubiquitin-specific-processing protease FAF-X antibody, anti Fafl antibody, anti Fam antibody, anti DFFRX antibody, anti FAF antibody, anti FAFL antibody, anti FAM antibody

Quick Database Links

UniProt

P70398