VER-49009

SKU: orb1304188

Description

VER-49009

Research Area

Product Categories/Products/Small Molecules,Cytoskeletal Signaling|||Metabolism

Key Properties

• CAS Number: 558640-51-0
• MW: 387.82
• Purity: 99.99%
• Formula: C₁₉H₁₈ClN₃O₄
• SMILES: CCNC(=O)c1n[nH]c(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O

Bioactivity

• Target IC50:
  HSP90:25 nM|HSP90:78 nM(kd)
• In Vivo:
  Treatmented with VER-49009 results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors.
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• In Vitro:
  VER-49009 inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells.
• Cell Research:
  Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

4369536