Wnt-C59

SKU: orb181132

Description

Wnt-C59(C59) is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [1243243-89-1]
• MW: 379.45
• Formula: C₂₅H₂₁N₃O
• SMILES: CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Chemical Structure of Wnt-C59

Kuo, Hui-Hsuan et al. Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture Stem Cell Reports, 14, 256-270 (2020)

PubMed: 31928950

Applications

Cell Culture

Reactivity

Human

Sharma, Arun et al. Differentiation and Contractile Analysis of GFP-Sarcomere Reporter hiPSC-Cardiomyocytes Curr Protoc Hum Genet, 96, (2018)

PubMed: 29364522

Applications

Cell Culture

Reactivity

Human

K Ashley Fetterman 1, Malorie Blancard 1, Davi M Lyra-Leite 1, Carlos G Vanoye 2, Hananeh Fonoudi 1, Mariam Jouni 1, Jean-Marc L DeKeyser 1, Brian Lenny 3, Yadav Sapkota 3, Alfred L George Jr 1, Paul W Burridge Independent compartmentalization of functional, metabolic, and transcriptional maturation of hiPSC-derived cardiomyocytes Cell Rep, 43, 114160 (2024)

PubMed: 38678564

Shan, Dan et al. Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H2O2-Activated PKC-δ Signaling Circulation, (2020)

PubMed: 32677469

Applications

Cell Culture

Reactivity

Human