WQ-C-401

SKU: orb2664877

Description

WQ-C-401 is an orally active inhibitor of the platelet-derived growth factor receptor (PDGFR). It inhibits cell proliferation by blocking PDGFR auto-phosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRαY849 and 5.8 nM for PDGFRβY1021. Additionally, WQ-C-401 suppresses the proliferation and migration of PASMCs by inhibiting PDGF-BB-induced phosphorylation of ERK1/2, reduces collagen I synthesis, and increases α-SMA expression, thereby preventing pulmonary vascular remodeling. This compound shows promise for research in the field of pulmonary arterial hypertension.

Research Area

,Tyrosine Kinase/Adaptors|||Angiogenesis|||MAPK

Key Properties

• CAS Number: 2376694-72-1
• MW: 418.49
• Purity: 98.00%
• Formula: C₂₄H₂₆N₄O₃
• SMILES: O=C(NC1=CC=C(C(OC2CCN(C(=O)C=3N=CN(C3)C)CC2)=C1)C)C=4C=CC=CC4

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139518716