YTHDC1 inhibitor 40 (compound 40)

SKU: orb2703445

Description

YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM. Compound 40 shows antiproliferative activity against the acute myeloid leukemia (AML) cell lines THP-1, MOLM-13, and NOMO-1.YTHDC1 inhibitor 40 exhibits antiproliferative activity against THP-1 (GI50 = 3.2 μM), MOLM-13 (5.6 μM) and NOMO-1 (8.2 μM), respectively. YTHDC1 inhibitor 40 displays IC50 values of 89, 60, and 83 μM against YTHDF1, YTHDF2, and YTHDF3, respectively, indicating a 200-fold selectivity.YTHDC1 inhibitor 40 does not display significant inhibition of a panel of 58 protein kinases.YTHDC1 inhibitor 40 (2.5-10 uM) induces apoptosis in THP-1 cell line after 24 h treatment.YTHDC1 inhibitor 40 is a tool compound for studying the role of YTHDC1 in AML.

Key Properties

• CAS Number: [2995344-53-9]
• MW: 308.17
• Formula: C₁₃H₁₁Cl₂N₅
• SMILES: CNC1=NC(Cl)=NC2=C(CC3=CC=CC(Cl)=C3)NN=C21

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only