ZX-29

SKU: orb2703622

Description

ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect.

Key Properties

• CAS Number: [2254805-62-2]
• MW: 518.03
• Formula: C₂₃H₂₈CLN₇O₃S
• SMILES: N1(C2=CC(OC)=C(C=C2)NC2N=C(NC3=C(C=CC=C3)NS(=O)(=O)C)C(Cl)=CN=2)CCN(C)CC1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only