Anti-HLA-C Purified

SKU: orb1088498

Description

HLA-C, a member of MHC class I glycoproteins, is one of polymorphysm typing targets, which are important for transplantation. The HLA system plays an important role in the occurrence and outcome of infectious diseases. The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population. It has been described that HLA-C interacts with human herpesvirus 8 MIR1 protein.

Research Area

Epigenetics, Immunology, Infectious Diseases

Images & Validation

• Tested Applications: FC, IP
• Reactivity: Human, Primate
• Application Notes:
  Flow cytometry: Recommended dilution: 1-4 μg/ml.

Key Properties

• Antibody Type: Primary Antibody
• Clonality: Monoclonal
• Isotype: Mouse IgG2b
• Clone No.: DT-9
• Immunogen: Purified MHC class I molecules of tamarin origin
• Target: HLA-C
• Purity: Purified by protein-A affinity chromatography.
• Purification: Purified by protein-A affinity chromatography.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anti-HLC-C antibody, anti-D6S204 antibody, anti-PSORS1 antibody, anti-HLA-JY3 antibody

Separation of lymphocytes stained anti-human HLA-C (DT-9) purified antibody (concentration in sample 1.7 μg/ml, GAM APC, red-filled) from lymphocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human HLA-C (DT-9) purified antibody (concentration in sample 1.7 μg/ml, GAM APC).

Quick Database Links

Gene Symbol

HLA-C

UniProt

P10321

NCBI Gene ID

3107