B7H4

SKU: orb1945864

Description

B7-H4 is a glycosylated transmembrane protein of the B7 family. It binds to activated T cells to moderate the T cell responses via cell cycle arrest in the T cell. Reverse signaling can induce either cell cycle arrest or apoptosis in the B7-H4 expressing cell. B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status.

Images & Validation

• Tested Applications: IHC
• Reactivity: Human

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone No.: IHC104
• Conjugation: Unconjugated

Storage & Handling

• Storage: Store at 2-8°C. To ensure stability, immediately replace vial back in the refrigerator after each use
• Buffer/Preservatives: Tris Buffer, pH 7.3 - 7.7, with 1% rAlbumin and < 0.1% Sodium Azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only