HRX-0233

SKU: orb2279904

Description

HRX-0233 (HRX0233) is a potent and selective inhibitor of MAP2K4 (MKK4), a kinase involved in the stress-activated protein kinase (SAPK) signaling pathway. MAP2K4 plays a role in regulating cellular responses to stress, apoptosis, and tumorigenesis. HRX-0233 has shown particular promise in KRAS-mutant cancers, where it exhibits synergistic effects with RAS inhibitors, making it a potential candidate for combination therapy in these difficult-to-treat cancers.

Key Properties

• CAS Number: [2409140-12-9]
• MW: 497.52
• Formula: C₂₄H₂₁F₂N₅O₃S
• SMILES: O=C(C1=CNC2=NC=C(C3=CN=C(C4CC4)N=C3)C=C21)C5=CC=C(C(NS(=O)(CCC)=O)=C5F)F

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only