HRX-0233

SKU: orb2665556

Description

HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.

Key Properties

• CAS Number: 2409140-12-9
• MW: 497.52
• Purity: 98.00%
• Formula: C₂₄H₂₁F₂N₅O₃S
• SMILES: O=C(C1=CC=C(F)C(NS(=O)(=O)CCC)=C1F)C2=CNC3=NC=C(C=C32)C=4C=NC(=NC4)C5CC5

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146302453