Human IL-7 protein

SKU: orb107750

Description

Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. IL-7 binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation ofhematopoietic stem cells into lymphoid progenitor cells. It also stimulates proliferation of B cells, T cells and NK cells. MurineIL-7 has approximately 65% and 88% amino acid sequence identity with human and rat IL-7 and both proteins exhibit crossspeciesactivity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies andduring HIV infection.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-7
• Conjugation: Unconjugated
• MW: 17.4 kDa
• Purity: > 96% by SDS-PAGE and HPLC analyses
• Protein Sequence: DCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDANKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGRKPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 2% trehalose
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Interleukin-7 protein

SDS-PAGE analysis of Human IL-7 protein

Quick Database Links

Gene Symbol

IL-7