NSE

SKU: orb1945576

Description

Neuron-Specific Enolase (NSE), also known as Enolase 2 (ENO2), is one of three enolase enzymes found in mammals, and acts as a phosphopyruvate hydratase. This mammalian glycolytic isoenzyme is located specifically in neurons of neuroendocrine cells, as well as tumours associated with those neurons. However, it has also been detected immunohistochemically in non-neoplastic cells of the pituitary, peptide-secreting tissues, pinealocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, islets of Langerhans, Merkel cells of the skin, and melanocytes. NSE is a useful marker for identifying normal striated muscle, hepatocytes, and peripheral nerves. Anti-NSE may detect for neuroendocrine differentiation, only when used in a panel of antibodies including more specific markers such as synaptophysin, chromogranin, and neurofilament.

Images & Validation

• Tested Applications: IHC
• Reactivity: Human

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a, kappa
• Clone No.: IHC641
• Conjugation: Unconjugated

Storage & Handling

• Storage: Store at 2-8°C. To ensure stability, immediately replace vial back in the refrigerator after each use
• Buffer/Preservatives: Tris Buffer, pH 7.3 - 7.7, with 1% rAlbumin and < 0.1% Sodium Azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only