Rat BD-3 protein

SKU: orb107689

Description

Beta defensin-3, also known as BD-3 and DEFB-3, is a membrane active cationic peptide that functions in inflammation andinnate immune responses and coded by Defb 3 gene on chromosome 8 in mouse. There are at least 30 E-defensins which aredistinguished from F-defensins by the connectivity pattern of their three intramolecular disulfide bonds. BD3 is widely expressedamong epithelial tissues, notably by keratinocytes and airway epithelial cells. It is upregulated in response to proinflammatorycytokines, microbial and viral infections, and at the edges of skin wounds. BD3 induction in osteoarthritis chondrocytes promotesMMP1 and 13 productions and inhibits TIMP1 and 2 expressions.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: BD-3
• Conjugation: Unconjugated
• MW: 4.5 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: KKVYNAVSCM TNGGICWLKC SGTFREIGSC GTRQLKCCKK K

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rat Beta Defensin-3 protein

SDS-PAGE analysis of Rat BD-3 protein

Quick Database Links

Gene Symbol

BD-3