Rat CNTF protein

SKU: orb107699

Description

Recombinant Rat Ciliary Neurotrophic Factor. Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Furthermore, the protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. Recombinant rat CNTF containing 199 amino acids and it shares 83 % and 95 % a.a. sequence identity with human and murine CNTF.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: CNTF
• Conjugation: Unconjugated
• MW: 22.7 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: AFAEQTPLTL HRRDLCSRSI WLARKIRSDL TALMESYVKH QGLNKNINLDSVDGVPVAST DRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPTEGDFHQAIHT LMLQVSAFAY QLEELMVLLE QKIPENEADG MPATVGDGGLFEKKLWGLKV LQELSQWTVR SIHDLRVISS HQMGISALES HYGAKDKQM

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 2xPBS, pH 7.4, 2mM C-mercaptoethanol.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rat CNTF protein

Quick Database Links

Gene Symbol

CNTF