Murine CNTF protein

SKU: orb107698

Description

Recombinant Murine Ciliary Neurotrophic Factor. Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Furthermore, the protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. Recombinant murine CNTF containing 197 amino acids and it shares 82 % and 95 % a.a. sequence identity with human and rat CNTF.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: CNTF
• Conjugation: Unconjugated
• MW: 22.4kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: AFAEQSPLTL HRRDLCSRSI WLARKIRSDL TALMESYVKH QGLNKNISLD SVDGVPVASTDRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPT EGDFHQAIHTLTLQVSAFAY QLEELMALLE QKVPEKEADG MPVTIGDGGLFEKKLWGLKVLQELSQWTVR SIHDLRVISS HHMGISAHES HYGAKQM

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 2xPBS, pH 7.4, 2% trehalose
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Murine Ciliary Neurotrophic Factor protein

Quick Database Links

Gene Symbol

CNTF