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Compound 401

SKU: orb1304029

Description

Compound 401

Research Area

Product Categories/Products/Small Molecules,DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling

Images & Validation

Key Properties

CAS Number168425-64-7
MW281.31
Purity99.76%
FormulaC16H15N3O2
SMILESO=c1cc(nc2c3ccccc3ccn12)N1CCOCC1

Bioactivity

Target IC50
DNA-PK:0.28 μM|mTOR:5.3 μM
In Vitro
Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 > 100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

Compound 401 (orb1304029)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 130.00
5 mg
$ 150.00
1 ml x 10 mm (in DMSO)
$ 160.00
10 mg
$ 160.00
25 mg
$ 220.00
50 mg
$ 330.00
100 mg
$ 440.00
200 mg
$ 580.00
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