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Compound 401

SKU: orb146120

Description

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 μM).

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Images & Validation

Key Properties

CAS Number[168425-64-7]
MW281.3092
FormulaC16H15N3O2
SMILESO1C([H])([H])C([H])([H])N(C2=C([H])C(N3C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C4C3=N2)=O)C([H])([H])C1([H])[H]

Storage & Handling

Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Compound 401

Chemical structure of Compound 401

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Protocol Information

Compound 401 (orb146120)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 ml x 10 mm (in DMSO)
$ 390.00
100 mg
$ 690.00
250 mg
$ 1,150.00
1 g
$ 2,190.00
DispatchUsually dispatched within 5-10 working days.
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