Human IL-36RA protein

SKU: orb107770

Description

Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RA hasbeen reported to antagonize the biological activity of IL-36G (IL-1F6), IL-36H (IL-1F8), and IL-36I (IL-1F9). Furthermore, itcould constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonistand interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirectevidence suggests it is IL-1Rrp2. Recombinant human IL-36 RA contains 154 amino acid residues and it shares 91 % a.a.sequence identity with murine IL-36RA.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-36RA
• Conjugation: Unconjugated
• MW: 16.8 kDa
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Protein Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGVQGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFLCTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 "m filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Interleukin-36 Receptor Antagonist Protein protein

SDS-PAGE analysis of Human IL-36RA protein

Quick Database Links

Gene Symbol

IL-36RA